For AMD, one of the most common causes of visual loss in elderly people, prior to the introduction of anti-vascular epithelial growth factor (VEGF) therapies, thermal laser photocoagulation or photodynamic therapy (PDT) with verteporfin were the preferred modalities for neovascular AMD, However, the regimen was highly dependent on the disease type and the location of the abnormal vascular leakage on fluorescein angiography [6]. This evidence concerns the gene VEGFA and age-related macular degeneration.