The levels of BACE1-AS are elevated in subjects with AD and its in vivo knock-down in mouse brain led to the downregulaton of BACE1 protein levels, reduction in amyloid-β synthesis and aggregation in the brain, signifying the importance of BACE1-AS for the development of AD (Modarresi et al., 2011). The gene discussed is BACE1; the disease is Alzheimer disease.