Somatic STK11 mutations have been observed in approximately 5% of sporadic PDAC, particularly those that arise in association within an IPMN, whereas loss of heterozygosity is seen in approximately 25% of patients with IPMN who lack PJS features (Sato et al., 2001; Hezel et al., 2006). Here, STK11 is linked to pancreatic intraductal papillary-mucinous neoplasm.