PALB2 and Fanconi anemia: The PALB2 gene encodes for a nuclear protein which co-localizes with BRCA1/2 in nuclear foci, acts as functional bridge between the two proteins, and provides stability to this complex by preventing proteosomal degradation, thereby allowing it to function in HR repair and checkpoint control as part of the Fanconi Anemia DNA repair pathway (Xia et al., 2006).