It also suppresses cellular transformation caused by oncogenic activation or loss of tumor suppressor pathways; thus, deletion or inactivation of TP53 is associated with aneuploidy, as well as the growth and survival of cells harboring chromosomal aberrations and genetic instability with potential for carcinogenic transformation (Schneider and Schmid, 2003; Hezel et al., 2006; Maitra et al., 2006; Koorstra et al., 2008). The gene discussed is TP53; the disease is neoplasm.