BRCA2 and pancreatic neoplasm: The overall prevalence of BRCA2 mutations in moderate-risk (two or more affected first-degree relatives) and high-risk (three or more affected first-degree relatives) pancreatic cancer families, was noted by Couch et al to be approximately 6% with a frequency ranging from 3 to 15% for families depending on the number of affected family members (Couch et al., 2007).