IGF1R and pancreatic neoplasm: In addition, there is aberrant activation and constitutive overexpression of the IGF-I receptor (IGF-IR) in approximately 64% of pancreatic tumor cells (Bergmann et al., 1995; Hakam et al., 2003; Ouban et al., 2003; Stoeltzing et al., 2003; Hezel et al., 2006).