The Cx26M34T mutant, which encodes full–length products, was originally described by Kelsell et al. (1997) who associated it with a dominant form of non-syndromic deafness (DFNA3) and also noted that M34 is conserved across several species both in Cx26 and in the closely related connexin 32 (Cx32) protein. This evidence concerns the gene GJB1 and nonsyndromic deafness.