Indeed, all the mouse mutants for genes associated with type 1 lissencephaly, or other similar cortical malformations (Lis1, Dcx, Tuba1a, reelin, Kif2a), have a CA3 lamination defect as a common, and the most obvious, feature (Figure 2, Hirotsune et al., 1998; Lambert de Rouvroit and Goffinet, 1998; Fleck et al., 2000; Corbo et al., 2002; Homma et al., 2003; Kappeler et al., 2007; Keays et al., 2007; Poirier et al., 2013). This evidence concerns the gene TUBA1A and classic lissencephaly.