In CIMP-positive HCT116 and HCT15 CRC cells (Zheng et al., 2000; Figure 6—figure supplement 3), ZNF304, KAP1, SETDB1, and DNMT1 were associated with the promoters of the nine CIMP marker genes (Figure 3—figure supplement 2, Figure 6—figure supplement 4), whose expression was derepressed by shRNA-mediated knockdown of ZNF304 or KRAS (Figures 2A and 3A, Figure 6—figure supplement 5). This evidence concerns the gene SETDB1 and colorectal carcinoma.