Figure 3I shows that ZNF304 was substantially enriched at the three promoters in CRC tumor samples relative to adjacent normal colon. Bisulfite sequencing analysis confirmed p14ARF promoter hypermethylation in the KRAS-positive CRC tumors but not in the matched normal colon (Figure 3—figure supplement 4). The gene discussed is ZNF304; the disease is colorectal carcinoma.