We next used a pathology tissue ChIP (PAT-ChIP) assay (Fanelli et al., 2011) to measure association of ZNF304 with p14ARF, p15INK4B, and p16INK4A promoters in KRAS-positive human CRC tumor samples and, as a control, adjacent matched normal colon. Here, CDKN2B is linked to colorectal carcinoma.