CDKN2B and colorectal carcinoma: In HCT116 and HCT15 CRC cell lines, in which INK4-ARF is transcriptionally silenced (Yagi et al., 2010), ZNF304 and its corepressors were associated with the p14ARF, p15INK4B, and p16INK4A promoters (Figure 3—figure supplement 2).