In HCT116 and HCT15 CRC cell lines, in which INK4-ARF is transcriptionally silenced (Yagi et al., 2010), ZNF304 and its corepressors were associated with the p14ARF, p15INK4B, and p16INK4A promoters (Figure 3—figure supplement 2). This evidence concerns the gene CDKN2A and colorectal carcinoma.