Most interestingly, PBRM1 and BAP1 mutations are mutually exclusive in ccRCC, and in a side-by-side comparison, PBRM1 mutation correlates with improved OS over BAP1 alterations (Kapur et al., 2013; Pena-Llopis et al., 2013). The gene discussed is PBRM1; the disease is nonpapillary renal cell carcinoma.