Clinically, DNMT3A mutations also correlated with increased age and predicted prognosis in all types, including worse OS, event-free survival (EFS), and AML-free survival (Lin et al., 2011; Neumann et al., 2013; Renneville et al., 2012; Thol et al., 2011b; Walter et al., 2011). This evidence concerns the gene DNMT3A and acute myeloid leukemia.