Uniquely, ccRCC harbors mutations in many of the KDMs, including KDM1A, KDM2B, KDM3A, KDM3B, KDM4A/B, and KDM5C (Dalgliesh et al., 2010; Hakimi et al., 2013a; Larkin et al., 2012; Shi et al., 2011). The gene discussed is KDM5C; the disease is nonpapillary renal cell carcinoma.