CREBBP and acute myeloid leukemia: Soon after these discoveries, the first genetic alteration of CREBBP in cancer was identified in M4/M5 AML subtypes, albeit a rare t(8,16)(p11,p13) translocation that fuses the MOZ gene with the N-terminus of CREBBP (Borrow et al., 1996; Panagopoulos et al., 2001).