DNMT3A mutations have also been described, albeit at lower frequency, in other myeloid malignancies, such as myelodysplastic syndromes (MDS; 3%–8%) and myeloproliferative neoplasms (MPNs; 2%–10%), as well as early T-cell precursor acute lymphoblastic leukemia (ETP-ALL; 16%–18%) (Brecqueville et al., 2011; Ewalt et al., 2011; Grossmann et al., 2013; Neumann et al., 2013; Stegelmann et al., 2011; Thol et al., 2011b; Traina et al., 2013; Walter et al., 2011). This evidence concerns the gene DNMT3A and acute lymphoblastic leukemia.