LATS1 and ovarian cancer: To investigate a role for YAP in ovarian cancer cell proliferation and metastasis, we generated A2780 and OVCAR8 stable cell lines that overexpressed constitutively active YAP (YAP with five LATS1/2 phosphorylation site mutations; YAP-5SA) and dominant negative YAP (YAP-5SA with a C-terminal transactivation domain deletion; YAP-5SA-ΔC; Figure 2B-C).