EDN1 and endothelial dysfunction: The dysfunction of the endothelium has been implicated in the pathophysiology of different forms of cardiovascular disease, including hypertension, coronary artery disease, chronic heart failure, peripheral artery disease etc. The pathophysiological mechanisms of endothelial dysfunction were related to a decrease in the bioavailability of NO as well as from augmented ET-1 synthesis, release, or activity [6].