MACF1 has no direct relation with cancer, it has been reported to function in the Wnt signaling pathway and to be associated with a complex containing Axin, beta-catenin, glycogen synthase kinase 3 (GSK3B), and adenomatous polyposis coli (APC) [69], which have been linked to tumorigenesis [70], [71]. The gene discussed is AXIN1; the disease is cancer.