For example, miR-196a has been studied for its oncogenic roles in glioblastoma, pancreatic adenocarcinoma, breast cancer, oesophageal adenocarcinoma, and colorectal cancer, and shown to target HOX family genes (HOXA7, HoxB7, HOXC8, HOXB8, HOXD8), ERG, HMGA2, ANXA1, S100A9, SPRR2C, KRTS [25], [26]–[31]. This evidence concerns the gene HOXD8 and esophageal adenocarcinoma.