KDR and cancer: In addition, there was no significant difference detected between RCC and non-RCC cancer in terms of the incidence of VEGFR-TKIs-associated all grade proteinuria (RR 1.05, 95% CI 0.88, 1.25, P = 0.60) and high grade proteinuria (RR 1.26, 95% CI 0.79, 2.02, P = 0.33) (table 3).