However, the unique overlapping hypodysplastic/nephrotic phenotype in which kidneys can presumably come from 2 different patients has not been described in other congenital nephrotic syndromes in which the defective protein is localized to glomeruli and not to early kidney precursors (e.g. nephrin, podocin) [20]. This evidence concerns the gene NPHS1 and familial nephrotic syndrome.