Recently, a Danish group has challenged this scenario, providing evidence that the proportion of newborns with detectable TEL-AML1 transcripts may actually be much lower (<0.01%) implying that a high proportion of infants, up to 100%, born with detectable TEL-AML1 fusion will eventually develop TEL-AML1+ ALL [22]. This evidence concerns the gene ETV6 and acute lymphoblastic leukemia.