Specifically, in CVID patients, median baseline IgG was 3.8 g/L (IQR: 1.7-4.4 g/L), median baseline IgA was 0.3 g/L (IQR: 0.05-1.00 g/l) and median baseline IgM was 0.3 g/L (IQR: 0.1-0.6 g/L). Here, CD40LG is linked to common variable immunodeficiency.