SH2B1 and obesity due to melanocortin 4 receptor deficiency: Our results showed that SH2B1 rs7498665 was significantly associated with the risk of overweight/obesity among 6,142 cases and 4,345 controls from four studies (overall OR = 1.21, 95% CI = 1.09-1.34, P = 0.0004, Figure 1).