PAK2 and breast cancer: For example, Li et al.[11] revealed that PAK2 was highly expressed in breast cancer cell lines and breast invasive ductal carcinoma tissue suggesting that highly expressed PAK2 might promote breast cancer progression and restrain the cell death response induced by chemotherapeutic drugs; Siu et al.[10] indicated that PAk2 and pPAK2 were both overexpressed in ovarian cancer cell lines and clinical samples of ovarian cancers compared with normal cell lines and benign ovarian lesions/inclusion cysts.