In the HFCC group, alterations in several proteins related to glucose metabolism were observed compared to the HF group, including the up-regulation of glycine N-methyltransferase, isoform CRA_a (GNMT) and the down-regulations of fructose-1,6-bisphosphatase 1 (FBP1) and regucalcin (Table 1). The gene discussed is RGN; the disease is hydrops fetalis.