To further confirm our hypothesis that resistance of TRAIL-mediated apoptosis may be due to promoter methylation, we monitored activation of caspase-8 and executioner caspases (caspases-3, -6, and -7) in uterine sarcoma cells which were treated for 5 days with 5-Aza-dC (Fig. 6). The gene discussed is TNFSF10; the disease is uterine corpus sarcoma.