As TRAIL acts in a similar way as TNF-α by binding to the cell membrane receptors DR4/TRAIL-R1 and/or DR5/TRAIL-R2 and by transmitting an apoptotic signal via their cytoplasmic death domain [20], we investigated whether a SAHA/TRAIL combination treatment enhances cell death in uterine sarcoma cell lines. The gene discussed is TNFRSF10A; the disease is uterine corpus sarcoma.