While only modest reduction in cell viability of HESC cells was observed even after 48 hours with any treatment (to ∼ 64% for SAHA or to ∼ 67% for SAHA/TRAIL treatment), the established working concentration of 3 μM SAHA and 100 ng/ml TRAIL proved to be very fast acting and effective on both investigated tumor cell lines with essentially all cells being eliminated. Here, TNFSF10 is linked to neoplasm.