To further investigate the chemopreventive activity of this compound in colon cancer and the mechanism underlying this effect, the expressions of Bax, proapoptotic proteins, B-cell lymphoma 2 (Bcl-2) (which has antiapoptotic effects) and cyclooxygenase 2 (COX-2) in the different groups were analyzed. The gene discussed is PTGS2; the disease is malignant colon neoplasm.