Remarkably, our previous findings showed that formononetin, another member of isoflavones family, successfully inactivated insulin-like growth factor 1 (IGF-1)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway in MCF-7 cells, leading to inhibition of cancer cell proliferation [16]. This evidence concerns the gene IGF1 and cancer.