Additionally, lower transcription of CCR6 continued to differentiate MDD patients from controls in both our discovery cohort (t = −1.841, d.f. = 58, p = 0.035, d = 0.483) and validation cohort (t = −1.799, d.f. = 23, p = 0.043, d = 0.750). Here, CCR6 is linked to major depressive disorder.