Similar to the cytoskeletal dynamics-related changes, several proteins that were differentially expressed during the time course of CHIKV infection in the brain were related to the endocytic machinery, including Rabaptin-5 (RABEP1), RAB35, N-ethylmaleimide–sensitive fusion protein (NSF), GRIP-associated protein 1 (GRIPAP1 or GRASP1), and annexin-A2 (ANXA2); this class of proteins was mainly down-regulated at the early stage of infection and then up-regulated at the later time-points (Figure 6). Here, ANXA2 is linked to infection.