CYTH2 and colorectal cancer: To detect the relationship of ARNO with cell proliferation and migration in colorectal cancer, we added sesinH3 to the culture medium and found it can reduce the proliferation (MTT assay with SecinH3 in 0(DMSO), 10, 20, and 40 μM for 24, 48, and 72 h) (Fig. 4b), and migration (Tran swell with SecinH3 in 0(DMSO), 10, 20 and 40 μM for 48 h) of HT29 and HCT116 cells (Fig. 4a).