CASP3 and neoplasm: The expression of pro-apoptotic proteins, Bax and cleaved form of caspase-3, -8, -9, as well as p21 and p53 was increased, whereas the expressions of Bcl2, xIAP, and cIAP2 were decreased by treatment of thiacremonone in both normal and PRDX6 overexpressed mice tumor tissues (Figure S2A).