Moreover, pathophysiological analysis of these tumors demonstrates that whereas the KRASG12V mice solely developed grade 1 adenomas (or adenomas with grade 1 nuclear atypia), mice expressing both CUX1 and KRASG12V developed higher grade adenomas (grades 1 and 2) and one large adenocarcinomas (Figure 2B). Here, CUX1 is linked to adenocarcinoma.