The dual role of CUX1 in cancer is illustrated by the fact that most cell lines with LOH of CUX1 display amplification of the remaining allele (http://cancer.sanger.ac.uk/cancergenome/projects/cell_lines/), suggesting that decreased CUX1 expression facilitates tumor initiation while increased CUX1 expression is associated with tumor progression. This evidence concerns the gene CUX1 and neoplasm.