In these tumor tissues, nuclear GSK3β might play a role in NF-κB -mediated cancer cell survival; however, after knockdown of GSK3β, the NF-κB expression levels in the different NSCLC cell lines of our study were inconsistent, indicating that GSK3β may mediate cancer cell survival independent of NFκB expression (data not shown). This evidence concerns the gene NFKB1 and non-small cell lung carcinoma.