In this context, the presence of reactive, oligoclonal CD8+ T-cells with features of LGL (which was termed the syndrome of T8 hyperlymphocytosis by previous authors, [5], [37]) or more rarely TCRγδ+/CD8+ T-cells ([38], present study) can be of diagnostic help in patients explored for a chronic neutropenia or a PRCA of unexplained origin. Here, CD8A is linked to pure red-cell aplasia.