CXCL12 and cancer: The CXC chemokine, stromal cell-derived factor (SDF)-1/CXCL12, and its G-protein-coupled receptor, CXCR4, are involved in cellular chemotaxis, angiogenesis, and cell proliferation [8], [9], and are involved in controlling development of the hematopoietic and vascular systems as well as playing a role in cancer metastasis [10].