Remodeling of the tumor stroma occurs through the induction of vascular endothelial growth factor (VEGF) and angiogenesis, dysregulated lymphangiogenesis, increased extracellular matrix deposition, and production of factors such as parathyroid hormone-related peptide (PTHrP) that increase osteoclastic activity [4], [8]–[10]. This evidence concerns the gene VEGFA and neoplasm.