The testosterone-induced changes we report in DRD2 gene expression in the nigrostriatal pathway at adolescence are of particular interest as DRD2 receptors are the target of all antipsychotic treatments for schizophrenia, with DRD2 receptors in the dorsal striatum suggested to be the most responsive to changes in tissue dopamine levels [7]. This evidence concerns the gene DRD2 and schizophrenia.