In terms of sex-specific influences of the APOA5–ZNF259 haplotype on the TG:HDL-C ratio and MS risk, rs6589566, which is located in the ZNF256 intron, will have an important role only in women, such that the major allele of the ZNF256 SNP in combination with the minor alleles of the two APOA5 SNPs can result in greater susceptibility to elevation of the TG:HDL-C ratio and MS risk (Tables 2 and 3). Here, ZNF256 is linked to myeloid sarcoma.