Compared with control Nkx3.1CreERT2/+; Pten+/+ mice with normal phenotype, Nkx3.1CreERT2/+; Ptenflox/flox mice develop high-grade prostatic intraepithelial neoplasia (PIN) and carcinoma following inducible deletion of Pten in the Nkx3.1 population [20]. This evidence concerns the gene PTEN and prostate intraepithelial neoplasia.