As expected, Kong et al [36] further report that PC3 prostate cancer cells which are forced to express PDGF-D display EMT characteristics and show cancer stem-like cell features after over-expression of pluripotency genes, such as the Nanog, Oct4, Sox2, Lin28 and activation of polycomb repressor complex, which is associated with increased clonogenic and prostasphere-forming capacity in vitro and tumorigenicity in vivo. The gene discussed is SOX2; the disease is Familial prostate cancer.