The simultaneous activation of both the TLR4 and PI3K pathways upon LPS stimulation has been reported to balance the pro-inflammatory and anti-inflammatory response [29]; Although the antagonist to TLR4 represents an emerging promising target for the treatment of sepsis; however, the role of PI3K pathway under TLR4-null conditions is not well understood. The gene discussed is TLR4; the disease is Sepsis.