The lack of detectable alterations in ACE and ET1 in the white matter does not therefore mean that drugs such as angiotensin type 1 receptor antagonists and ET1-receptor antagonists might not benefit perfusion of the white matter as well as the cortex in Alzheimer’s disease (as would a reduction in meningeal and cortical CAA). The gene discussed is EDN1; the disease is early-onset autosomal dominant Alzheimer disease.