OP compounds phosphorylate the active site of acetyl cholinesterase, inactivating the enzyme causing accumulation acetylcholine which stimulates excessively nicotinic and muscarinic receptors producing widespread clinical symptoms like nausea, vomiting, diarrhea, urinary incontinence, blurring of vision, salivation, lacrimation, broncorrhoea, bradycardia, hypotension, muscle paralysis, fasciculation, confusion, seizures, coma and respiratory failure[5]. Here, ACHE is linked to respiratory failure.