The authors concluded that signaling through STAT3-Snail-LIV-1 resulted in an increased expression of receptor activator of nuclear factor kB (NF-kB) ligand, which facilitates bone metastasis during prostate cancer progression Constitutive activation of STAT-3 has been observed in many human tumors including prostate [20]. The gene discussed is STAT3; the disease is prostate carcinoma.