Overexpression of miR-96 was a negative regulator of RAD51 foci formation, induced decrease of the efficiency of homologous recombination and enhancement of the sensitivity to the AZD2281 PARP inhibitor “in vitro” and to cisplatin both “in vivo” and “in vivo”, suggesting that miR-96 mimics could be used to enhance cancer chemosensitivity. The gene discussed is PARP1; the disease is cancer.