PARP inhibition with INO-1001 has been shown to restore sensitivity to TMZ in an MMR-deficient xenograft model of malignant melanoma (88), and another PARPi, GPI 15427, enhanced TMZ anti-tumor activity in various cancers, including metastatic melanoma in an orthotopic xenograft mouse model (24). Here, PARP1 is linked to neoplasm.