IGF1 and acromegaly: Both disorders of GH/IGF-1 axis activity including GH deficiency characterized by low serum IGF-1 and acromegaly accompanied by IGF-1 excess are associated with increased intima thickness [36, 37], So, a probably U-shaped association between the GH/IGF-1 axis activity and atherosclerosis was suggested though direct mechanisms of such a relation need to be elucidated [14].