Spearman's rank correlation analysis showed that 10 variables (age, TB, ALB, GLOB, AST, ALP, GGT, WBC, PLT, and PT) were correlated significantly with advanced liver fibrosis (correlation coefficients were 0.245, 0.213, −0.291, 0.249, 0.235, 0.223, 0.288, −0.258, −0.383, and 0.256, resp.; P values were 0.002, 0.007, <0.001, 0.002, 0.003, 0.005, <0.001, 0.001, <0.001, and 0.001 resp). The gene discussed is ALB; the disease is Hepatic fibrosis.