POMC and acromegaly: The clinical manifestation depends on the hormone produced by the paraganglioma and includes Cushing's syndrome (adrenocorticotropic hormone (ACTH)), hypercalcaemia (parathyroid-related peptide), inappropriate secretion of antidiuretic hormone syndrome (antidiuretic hormone), diarrhoea (intestinal vasoactive peptide) and acromegaly (growth hormone) (1).