Combined growth factor therapy might be an alternative that is worth exploring, as suggested by a recent report in the rat transgenic ALS model showing that VEGF and GDNF administered through an implant of human mesenchymal stem cells exert a synergistic protection in preserving nerve muscular synapses (Krakora et al., 2013). The gene discussed is GDNF; the disease is amyotrophic lateral sclerosis.