CNTF and motor neuron disorder: Subcutaneous injections of CNTF, which was effective in the mutant mice models of motor neuron disease pmn/pmn (Sendtner et al., 1992) and wobbler (Mitsumoto et al., 1994), did not affect the progression of disease in humans, but caused minor adverse side effects (ALS CNTF Treatment Study Group, 1996).