FOS and Hypoglycemia: In addition, insulin-induced hypoglycemia or neuroglucoprivation induces Fos expression in orexin neurons of the PeH suggesting a possible role in glucose sensing (Moriguchi et al., 1999; Briski and Sylvester, 2001; Cai et al., 2001; Paranjape et al., 2006; Tkacs et al., 2007).