The aim of this study was to investigate the association of cystic fibrosis transmembrane conductance regulator (CFTR) and serine protease inhibitor Kazal type 1 (SPINK-1) gene and Cathepsin B gene mutation with chronic pancreatitis (CP) and to associate genetic backgrounds with clinical phenotype in these three conditions. The gene discussed is CTSB; the disease is chronic pancreatitis.