Second, BIR can proceed through a non-homologous recombination mechanism by invading microhomologous DNA sequences (MMBIR, microhomology-mediated BIR) 59, which might explain the presence of microhomologies at the breakpoints of complex genomic rearrangements that have been associated with genetic diseases and cancer 54,60. The gene discussed is KCNJ11; the disease is hereditary disease.