PLOD1 and hypogonadotropic hypogonadism: Kisspeptin-10 also stimulated LH pulse frequency in diabetic men with hypogonadotropic hypogonadism, which was sustained for the duration of the infusion (11 h) with no evidence of a decline in LH (i.e. no desensitization) over that timescale (George et al., 2013).