The ability of kisspeptin to enhance LH pulsatility has also been demonstrated in human reproductive disorders, including in hypothalamic amenorrhoea (Jayasena et al., 2013a), in hypogonadal men with type 2 diabetes (George et al., 2013) and in neurokinin B signalling defects (Young et al., 2013), described more fully below. This evidence concerns the gene PLOD1 and type 2 diabetes mellitus.