In a study by Yki JH et al [16], 96 patients with type 2 diabetes to 1 year of treatment were randomized to receive bedtime insulin plus glyburide and placebo, metformin and placebo, glyburide and metformin, or a second injection of insulin and were evaluated with their effects on weight gain, frequency of hypoglycemic episodes, and glycemic control in patients with type 2 diabetes whose disease was inadequately controlled with sulfonylurea therapy alone. The gene discussed is INS; the disease is type 2 diabetes mellitus.