BDNF and Bartsocas-Papas syndrome 1: Although the decrease of urinary NGF and NGF/Cr levels and the improvement of clinical parameters were noted after HA treatment, urinary NGF, NGF/Cr and BDNF levels in HA treated IC/BPS patients were still significantly higher than in controls, except for urinary BDNF/Cr levels (p  =  0.08).