In contrast to MCA-205 cells, challenge of mice with MCA-205-OVA, MCA-205-E1A-Δp300-OVA or MCA-205-E1A-OVA resulted in an equivalent expansion of OT-II cells present in the draining lymph node (Figure 3 B, C) Collectively these data indicate that challenge of mice with MCA-205-OVA, MCA-205-E1A-Δp300-OVA or MCA-205-E1A-OVA tumor cells induced an OVA-specific CD4 and CD8 T cell response. The gene discussed is CD4; the disease is neoplasm.