1×106 CD45.1+OT-II CD4 T cells isolated from CD45.1+OT-II+RAG−/− mice were adoptively transferred into CD45.2+ B6 mice and 24 hours later mice were challenged with MCA-205, MCA-205-OVA, MCA-205-E1A-Δp300-OVA, and MCA-205-E1A-OVA tumor lines. The gene discussed is CD4; the disease is neoplasm.